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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Successful osimertinib rechallenge without concomitant corticosteroids after osimertinib-induced pneumonitis

Taisuke Ito1, Kazuo Tsuchiya1, Rie Mori1

  • 1Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Shizuoka City, Shizuoka, Japan.

Respiratory Medicine Case Reports
|May 7, 2024
PubMed

A 60-year-old woman was diagnosed with cT4N3M1c stage IVB lung adenocarcinoma with epidermal growth factor receptor mutation of exon19 deletion. After one month of treatment with osimertinib, a cough and diffuse ground glass opacities were observed in the bilateral lung field. Based on the clinical course and the exclusion of other etiologies, osimertinib-induced pneumonitis was diagnosed. The shadows resolved after osimertinib was discontinued. However, brain metastasis and leptomeningeal metastasis developed 20 months later; therefore, osimertinib was re-administered without concomitant corticosteroids. The pulmonary lesion and leptomeningeal metastasis were successfully treated without recurrence of drug-induced pneumonitis for eight months.

Keywords:
DesensitizationEGFR-TKIOsimertinibOsimertinib-induced pneumonitisRe-administration

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