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Related Experiment Video

Updated: Jun 27, 2025

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
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Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering.

Wei Luo1, Hanli Zhang1, Renwen Wan1

  • 1Department of Sports Medicine Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.

Advanced Healthcare Materials
|May 7, 2024
PubMed
Summary

Skeletal muscle tissue engineering (SMTE) uses advanced biomaterials to improve healing for severe injuries where natural regeneration is insufficient. These materials provide structural support and deliver regenerative cues for better skeletal muscle repair.

Keywords:
3D bioprintingbiomaterialsexosomesmicro/nanotechnologiesncRNAskeletal muscletissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Severe skeletal muscle injuries often exceed the body's natural healing capabilities.
  • Skeletal muscle tissue engineering (SMTE) aims to address this clinical need by developing artificial solutions.
  • Advances in micro/nanotechnology and 3D printing have enabled sophisticated approaches to SMTE.

Purpose of the Study:

  • To review the structure and regeneration processes of skeletal muscle.
  • To explore diverse biomaterial systems developed for SMTE.
  • To discuss the role of biomaterials in facilitating skeletal muscle repair and translation to clinical applications.

Main Methods:

  • Discussion of skeletal muscle structure and regeneration mechanisms.
  • Exploration of various biomaterial systems and their applications in SMTE.
  • Analysis of cellular and molecular perspectives on biomaterial-driven regeneration.

Main Results:

  • Biomaterials function as scaffolds providing structural and physicochemical cues (topographical, electrical, mechanical).
  • Biomaterials act as delivery systems for stem cells and bioactive molecules crucial for repair.
  • Insights into molecular mechanisms underlying biomaterial-enhanced skeletal muscle regeneration are provided.

Conclusions:

  • Biomaterial systems are critical for advancing skeletal muscle tissue engineering.
  • Future directions include gene therapy, exosomes, and hybrid biomaterials for enhanced SMTE.
  • Bridging the gap from laboratory research to clinical application is a key focus for SMTE development.