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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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Related Experiment Video

Updated: Jun 27, 2025

FISH for Pre-implantation Genetic Diagnosis
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Optical Genome Mapping in Prenatal Diagnosis: Democratizing Comprehensive Cytogenomic Testing

Mariam T Mathew1,2,3, Yassmine M N Akkari1,2

  • 1The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, United States.

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|May 7, 2024
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No abstract available in PubMed .

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