Causal association between urine albumin-to-creatinine ratio and risk of colorectal cancer: A two-sample Mendelian randomization study
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View abstract on PubMed
Summary
This summary is machine-generated.This study found no causal link between urine albumin-to-creatinine ratio (ACR) and colorectal cancer (CRC) risk. These findings suggest ACR is not a reliable marker for predicting CRC development.
Area Of Science
- Genetics
- Oncology
- Nephrology
Background
- Observational studies on urinary albumin excretion and colorectal cancer (CRC) risk have yielded inconsistent results.
- A causal relationship between urine albumin-to-creatinine ratio (ACR) and CRC risk remains unclear.
Purpose Of The Study
- To investigate the potential causal association between genetically predicted ACR and CRC risk using a two-sample Mendelian randomization (MR) analysis.
- To determine if ACR serves as a reliable biomarker for CRC development.
Main Methods
- Utilized genome-wide association study (GWAS) data for ACR and CRC from large-scale databases.
- Employed two-sample MR analysis with robust statistical methods (inverse-variance weighted, MR-Egger, weighted median) and sensitivity analyses (MR-PRESSO, leave-one-out).
- Analyzed genetic variations as instrumental variables for ACR to infer causality.
Main Results
- Genetically predicted ACR was not significantly associated with overall CRC risk.
- No significant association was observed between ACR and risk for colon or rectal cancer specifically.
- Sensitivity analyses confirmed the robustness and reliability of the findings, indicating no evidence of pleiotropy.
Conclusions
- The study suggests that ACR does not causally influence CRC risk.
- ACR is unlikely to be a useful clinical marker for assessing CRC risk.
- Further research, particularly in diverse ethnic populations, is warranted to confirm these findings.
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