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The multifaceted role of the mineralocorticoid receptor in cancers

Tram B Doan1, J Dinny Graham2

  • 1Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.

The Journal of Steroid Biochemistry and Molecular Biology
|May 7, 2024
PubMed

Insights

The mineralocorticoid receptor (MR) plays a role in cancer, unlike other steroid receptors. This review explores MR's potential functions and mechanisms in cancer biology.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • The mineralocorticoid receptor (MR/NR3C2) is a nuclear receptor, part of the steroid receptor (SR) family.
  • Other SRs like estrogen, progesterone, and androgen receptors are established in cancer pathogenesis.
  • The role of MR in cancer biology remains largely unexplored.

Purpose of the Study:

  • To review current understanding of the mineralocorticoid receptor's role in cancer.
  • To examine potential mechanisms by which MR influences cancer development and progression.

Main Methods:

  • Literature review of existing research on MR and cancer.
  • Analysis of studies investigating MR's function in various cancer types.

Main Results:

  • Emerging evidence suggests MR is implicated in cancer biology.
  • Potential mechanisms include regulation of gene expression and cellular processes relevant to cancer.

Conclusions:

  • MR represents a potential target for cancer therapy.
  • Further research is needed to fully elucidate MR's complex role in oncogenesis.
Keywords:
CancerMineralocorticoid receptorSteroids

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