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Thymic lymphocyte differentiation and thymic leukemogenesis.

International Journal of Radiation Oncology, Biology, Physics

|January 1, 1985

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Bone marrow precursors lacking T cell markers give rise to thymic lymphocytes. These lymphocytes mature through contact with various non-lymphoid cells, with specific subsets expressing unique receptors for viral lymphomagenesis.

Area of Science:

Immunology
Cell Biology
Virology

Background:

Studies on radiation leukemogenesis established lymphocyte biology and viral leukemogenesis.
Research continued dual focus on thymic lymphocytopoiesis and lymphomagenesis.

Purpose of the Study:

To demonstrate the origin and maturation process of thymic lymphocytes.
To identify non-lymphoid cells involved in T cell maturation within the thymus.
To characterize thymic target cells for retrovirus-induced lymphomagenesis.

Main Methods:

Tracing the differentiation of bone marrow precursors within the thymus.
Investigating interactions between lymphocytes and non-lymphoid thymic cells.
Analyzing cell surface receptors on thymic emigrants and lymphomagenesis target cells.

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Main Results:

Thymic lymphocytes originate from T cell marker-negative bone marrow precursors.
Bone marrow precursors can generate both cortical and medullary thymic progeny.
Maturation involves interaction with thymic nurse cells, dendritic epithelial cells, medullary epithelial cells, dendritic reticular cells, and macrophages.
Cortical dendritic epithelial cells exhibit unique MHC antigen distribution potentially for T cell restriction.
Emigrating thymocytes express peripheral lymphoid organ homing receptors.
Retrovirus lymphomagenesis targets cells with receptors analogous to antigen-specific T cell receptors.

Conclusions:

Bone marrow precursors are the source of thymic lymphocytes.
Thymic lymphocytes undergo a complex maturation process involving multiple non-lymphoid cell types.
Specific cell surface receptors play roles in T cell maturation, homing, and susceptibility to viral lymphomagenesis.