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Related Experiment Video

Updated: Jun 27, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
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Extracellular vesicles in atherosclerosis: Current and forthcoming impact.

José A Páramo1, Ana Cenarro2, Fernando Civeira2

  • 1Hematology Service, Clínica Universidad de Navarra, Pamplona, Spain; Laboratory of Atherothrombosis, Cima Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBERCV, ISCIII, Madrid, Spain.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|May 7, 2024
PubMed
Summary

Extracellular vesicles (EVs) are key in atherosclerosis, a cardiovascular disease process. These tiny particles offer potential as biomarkers for diagnosing and predicting cardiovascular diseases and understanding arterial remodeling.

Keywords:
ArteriosclerosisAtherosclerosisBiomarcadorBiomarkerComunicación intercelularExtracellular vesiclesIntercellular communicationVesículas extracelulares

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Area of Science:

  • Cardiovascular Biology
  • Cellular and Molecular Medicine
  • Biomarker Discovery

Background:

  • Atherosclerosis, a primary cause of cardiovascular diseases (CVDs), is now understood as an active inflammatory process, not just cholesterol buildup.
  • Despite advances, CVD patients face significant risks of thrombotic events and mortality, necessitating deeper understanding of atherogenesis.
  • Novel diagnostic and prognostic biomarkers are crucial for patient stratification in CVDs.

Purpose of the Study:

  • To review the role of extracellular vesicles (EVs) as potential biomarkers in cardiovascular diseases (CVDs).
  • To explore the involvement of EVs in the molecular mechanisms underlying atherogenesis and arterial remodeling.
  • To highlight EVs as potential tools for understanding cell-to-cell communication in atherosclerosis.

Main Methods:

  • Literature review focusing on extracellular vesicles (EVs) and atherosclerosis.
  • Analysis of current research on EV composition (lipids, proteins, nucleic acids) and their relation to parental cell status.
  • Synthesis of findings on EVs' role in cellular processes and their potential as biomarkers for cardiovascular diseases.

Main Results:

  • Extracellular vesicles (EVs) are increasingly recognized for their active roles in cellular processes, moving beyond their initial perception as mere cellular waste.
  • EVs carry molecular cargo reflecting the physiological and pathological state of their parent cells.
  • EVs show significant promise as diagnostic and prognostic biomarkers for cardiovascular diseases (CVDs).

Conclusions:

  • Extracellular vesicles (EVs) are crucial players in the complex processes of atherogenesis.
  • EVs represent a promising avenue for developing novel biomarkers for cardiovascular diseases (CVDs).
  • Further research into EVs can illuminate the molecular mechanisms of atherosclerosis and improve patient management.