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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Jun 27, 2025

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
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Neuroendocrine Tumors: Diagnostics.

Christopher Sakellis1, Heather A Jacene1

  • 1Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, DL198, Boston, MA 02215, USA; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215, USA.

PET Clinics
|May 7, 2024
PubMed
Summary

Neuroendocrine neoplasms (NEN) benefit from somatostatin receptor (SSTR) imaging, particularly with advanced SSTR PET radiotracers. This imaging is crucial for identifying NEN, assessing treatment response, and determining eligibility for peptide receptor radionuclide therapy.

Keywords:
DotatateGa68Neuroendocrine neoplasmNeuroendocrine tumorPETPRRTSomatatostatin receptor

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Neuroendocrine neoplasms (NEN) are rare tumors originating from neuroendocrine cells.
  • NEN exhibit specific somatostatin receptor (SSTR) expression, making them suitable for theranostic approaches.
  • SSTR imaging has advanced significantly with sensitive SSTR PET radiotracers.

Purpose of the Study:

  • To review the evolving role of imaging in managing neuroendocrine neoplasms.
  • To highlight the importance of SSTR PET in NEN diagnosis and characterization.
  • To emphasize SSTR PET's role in treatment response assessment and therapy selection.

Main Methods:

  • Review of current literature on SSTR imaging in NEN.
  • Focus on the diagnostic and therapeutic implications of SSTR PET.
  • Comparison of SSTR PET with traditional anatomic imaging modalities.

Main Results:

  • SSTR PET is a primary modality for identifying NEN and assessing SSTR expression.
  • SSTR PET complements anatomic imaging in evaluating treatment response.
  • SSTR PET is essential for determining patient eligibility for peptide receptor radionuclide therapy.

Conclusions:

  • Advanced SSTR PET imaging plays a pivotal role in the comprehensive management of NEN.
  • The theranostic potential of SSTR-targeted agents is enhanced by sensitive PET imaging.
  • Imaging is indispensable for personalized treatment strategies in NEN patients.