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Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China
Yin-Shan Wang1,2, Xue-Ting Su3, Li Ke4,5
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Insights
Adverse perinatal factors impact children's brain development and mental health. The new periCBD database offers a vital resource for understanding these complex relationships in children aged 3-10 years.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Background:
- Adverse perinatal factors can disrupt typical brain development, leading to lasting effects on children's overall development.
- Current understanding of cognitive and neurodevelopmental processes influenced by perinatal adversities is limited.
- A comprehensive, open-access resource is needed to link perinatal factors with brain and mental health development.
Purpose of the Study:
- Introduce the peri--Clinical Brain Development (periCBD) database, a multicenter resource.
- Facilitate research into individual differences in brain-mind development linked to perinatal factors.
- Investigate the specific impacts of adverse perinatal factors on cognitive and neurodevelopment in children.
Main Methods:
- Established a multicenter database (periCBD) integrating neuroimaging, behavioral phenotypes, and perinatal data.
- Collected data from children aged 3-10 years across county, region, and central district hospitals.
- Detailed data acquisition, cleaning, quality control, and sharing protocols were implemented.
Main Results:
- The periCBD database provides a rich, integrated dataset for studying brain-mind development.
- The data descriptor systematically outlines the database's structure and content.
- The resource is designed for investigating associations between perinatal factors and child development.
Conclusions:
- The periCBD database represents a significant step towards understanding the impact of perinatal factors on child development.
- This open resource will enable deeper insights into neurodevelopmental trajectories and mental health outcomes.
- Future research can leverage periCBD to explore specific adverse perinatal influences on cognitive functions.
Abstract:
Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognitive and neurodevelopmental processes under conditions of adverse perinatal factors is substantially limited. There is a critical need for an open resource that integrates various perinatal factors with the development of the brain and mental health to facilitate a deeper understanding of these developmental trajectories. In this Data Descriptor, we introduce a multicenter database containing information on perinatal factors that can potentially influence children's brain-mind development, namely, periCBD, that combines neuroimaging and behavioural phenotypes with perinatal factors at county/region/central district hospitals. PeriCBD was designed to establish a platform for the investigation of individual differences in brain-mind development associated with perinatal factors among children aged 3-10 years. Ultimately, our goal is to help understand how different adverse perinatal factors specifically impact cognitive development and neurodevelopment. Herein, we provide a systematic overview of the data acquisition/cleaning/quality control/sharing, processes of periCBD.
