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Updated: Jun 27, 2025
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Gender differences in the association between changes in the atherogenic index of plasma and cardiometabolic
Xingjie Huang1, Song Wen2, Yuqing Huang3
1Department of Cardiology, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541000, Guangxi, China.
Insights
Significant changes in Atherogenic Index of Plasma (AIP) increase cardiometabolic disease (CMD) risk in older Chinese males. Dynamic AIP monitoring is crucial for CMD prevention and treatment.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome Research
- Geriatric Medicine
Background:
- The link between Atherogenic Index of Plasma (AIP) fluctuations and cardiometabolic diseases (CMD) in older adults is not well-established.
- Understanding this relationship is vital for developing targeted preventive strategies.
Purpose of the Study:
- To investigate the association between changes in AIP and the incidence of CMD in individuals over 45 years old.
- To explore gender-specific differences in the relationship between AIP dynamics and CMD risk.
Main Methods:
- Utilized data from 3,791 Chinese adults aged over 45 from the CHARLS cohort.
- Employed K-Means clustering to categorize participants based on AIP changes and logistic regression to analyze CMD risk.
- Applied restricted cubic splines to assess the dose-response relationship between cumulative AIP and CMD.
Main Results:
- Increased AIP changes were independently associated with higher CMD risk, particularly in males (OR 1.75).
- Cumulative AIP showed a positive correlation with CMD (OR 1.15), with significant gender differences observed.
- A linear relationship between cumulative AIP and CMD was identified in males.
Conclusions:
- Substantial shifts in AIP may elevate CMD risk in middle-aged and elderly Chinese men.
- Continuous monitoring of AIP is essential for effective CMD prevention and management in at-risk populations.
Objective:
The relationship between changes in Atherogenic Index of Plasma (AIP) and cardiometabolic diseases (CMD) in middle-aged and elderly individuals remains unclear. This study aims to explore the association between changes in AIP and CMD.
Methods:
This study included 3,791 individuals aged over 45 years from CHARLS. Participants were divided into four groups using the K-Means clustering method. Cumulative AIP was used as a quantitative indicator reflecting changes in AIP. Differences in baseline data and CMD incidence rates among these four groups were compared. Multifactorial logistic regression models were used to assess the relationship between changes in AIP and CMD, and subgroup analysis and interaction tests were conducted to evaluate potential relationships between changes in AIP and CMD across different subgroups. Restricted cubic splines (RCS) were used to assess the dose-response relationship between cumulative AIP and CMD.
Results:
Changes in AIP were independently and positively associated with CMD. In males, the risk significantly increased in class4 compared to class1 (OR 1.75, 95%CI 1.12-2.73). In females, changes in AIP were not significantly associated with CMD. Cumulative AIP was positively correlated with CMD (OR 1.15, 95%CI 1.01-1.30), with significant gender differences in males (OR 1.29, 95%CI 1.07-1.55) and females (OR 1.03, 95%CI 0.87-1.23) (p for interaction = 0.042). In addition, a linear relationship was observed between cumulative AIP and CMD in male.
Conclusion:
Substantial changes in AIP may increase the risk of CMD in middle-aged and elderly Chinese males. Dynamic monitoring of AIP is of significant importance for the prevention and treatment of CMD.
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