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Updated: Jun 27, 2025
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Determinants of Kaposi Sarcoma during HIV infection: A nested case-control study from Yaoundé, Cameroon
Jobert Richie Nansseu1, Emmanuel Armand Kouotou2, Dahlia Noëlle Tounouga3
1Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaoundé, Cameroon; Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Background:
Although the burden of Kaposi sarcoma (KS) is fast increasing among HIV-infected populations, there is still critical lack of knowledge on its related driving factors in Cameroon. This study purposed to determine risk factors for KS in HIV-infected patients living in Yaoundé, Cameroon.
Methods:
This was a 1:3 case-control study nested on a retrospective cohort study, carried-out over a period of 16 years at the Yaoundé Central Hospital, Cameroon. Cases were HIV-infected patients, diagnosed with KS after histological confirmation. Controls were HIV-infected patients, naive of KS and paired to cases through age and sex. Logistic regression analyses served to identify risk factors for KS.
Results:
Of 14,220 files reviewed, 316 cases of KS (2.2%) were identified. We included 266 cases (55% males), to whom 798 controls were paired. The mean age of patients was 37.7 ± 9.6 years. Results of multivariable logistic regression analysis identified diabetes [adjusted odds ratio (aOR) 2.9, 95%CI: 1.3-7.7; p = 0.028] and HIV-related prurigo [aOR 0.3, 95%CI: 0.1-0.7; p = 0.010] as factors impacting significantly KS occurrence in this study.
Conclusion:
KS is frequent among our HIV-infected patients. Those having diabetes seem at increased odds of developing KS.
