Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Renal function in patients on lithium treatment.

R Hällgren, P O Alm, K Hellsing

The British Journal of Psychiatry : the Journal of Mental Science

|July 1, 1979

Summary

Lithium treatment may affect kidney function, with some patients showing decreased glomerular filtration rate and increased albumin or beta 2-microglobulin excretion. The cause of impaired renal function in these patients remains unclear.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cationic proteins of human granulocytes: Enhancement of phagocytosis ofStaphylococcus protein A-IgG complexes.

Inflammation·2013

Same author

Cationic proteins of human granulocytes Effects on human platelet aggregation and serotonin release.

Inflammation·2013

Same author

Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy.

Clinical nephrology·2010

Same author

Self-reported food intolerance and mucosal reactivity after rectal food protein challenge in patients with rheumatoid arthritis.

Scandinavian journal of rheumatology·2010

Same author

Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2008

Same author

Mucosal reactivity to cow's milk protein in coeliac disease.

Clinical and experimental immunology·2007

Area of Science:

Nephrology
Pharmacology
Clinical Chemistry

Background:

Lithium is a mood stabilizer used in treating bipolar disorder.
Potential adverse effects of long-term lithium therapy on kidney function are a concern.

Purpose of the Study:

To investigate kidney function in patients undergoing lithium treatment.
To assess glomerular filtration rate and urinary excretion of specific biomarkers.

Main Methods:

Cross-sectional study involving 66 lithium-treated patients.
Utilized [51Cr]-EDTA clearance to measure glomerular filtration rate.
Measured urinary albumin and beta 2-microglobulin excretion.

Main Results:

Thirteen patients (19.7%) exhibited abnormal kidney function tests.
Seven patients had reduced glomerular filtration rate.
Four patients each showed increased urinary albumin or beta 2-microglobulin excretion.
No correlation found between lithium treatment duration, hypothyroidism, and impaired renal function.
Four patients had pre-existing renal dysfunction before lithium treatment.

Conclusions:

A significant prevalence of impaired renal function was observed in lithium-treated patients.
The exact cause of renal dysfunction in this cohort is undetermined, but lithium is a potential contributing factor.
Further research is warranted to elucidate the relationship between lithium therapy and kidney health.

Related Experiment Videos