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Updated: May 6, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

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Ralstonia mannitolilytica Infections: A Systematic Review of Case Reports Unveiling Clinical Patterns and Therapeutic

Krishnapriya Neelambaran1, Hemasri Velmurugan1, Sajitha Venkatesan2

  • 1Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Current Drug Research Reviews
|May 8, 2024
PubMed
Abstract

Insights

Ralstonia mannitolilytica is an emerging pathogen threatening immunocompromised patients. This review of 17 case reports highlights catheter-related infections and sensitivity to third-generation cephalosporins like Ceftazidime.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Bacteriology

Background:

  • Ralstonia mannitolilytica is an emerging opportunistic pathogen.
  • It poses a significant threat to immunocompromised patients.

Purpose of the Study:

  • To evaluate the clinical impact of Ralstonia mannitolilytica infections.
  • To analyze management strategies for these infections.

Main Methods:

  • Systematic review of 17 case reports from PubMed (inception-July 31, 2023).
  • Data extraction followed PRISMA guidelines.
  • Case reports assessed using JBI critical appraisal checklist.

Main Results:

  • Catheter-related infections were predominant.
  • Sensitivity observed for third-generation cephalosporins, particularly Ceftazidime.
  • All included studies had a low risk of bias.

Conclusions:

  • Understanding Ralstonia mannitolilytica infections is crucial due to varied presentations and responses.
  • Precise identification and customized treatments are necessary.
  • Ongoing research is needed for effective management.
Keywords:
Pseudomonas thomasiiRalstonia mannitolilyticacase reportcatheter-related infections.emerging pathogenssystematic review

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