Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
The Cell Cycle Control System01:28

The Cell Cycle Control System

2.8K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.8K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

3.1K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.1K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal experiment design for practical parameter identifiability and model discrimination.

Mathematical biosciences·2026
Same author

Galvanin (TMEM154) is an electric-field sensor for directed cell migration.

Cell·2026
Same author

Modeling Collective Cell Migration in a Data-Rich Age: Challenges and Opportunities for Data-Driven Modeling.

Cold Spring Harbor perspectives in biology·2026
Same author

A likelihood-based Bayesian inference framework for the calibration of and selection between stochastic velocity-jump models.

Journal of the Royal Society, Interface·2026
Same author

Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes.

Research square·2026
Same author

Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids.

Nature physics·2026
Same journal

Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

Biophysical journal·2026
Same journal

Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

Biophysical journal·2026
Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026
Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

60.4K

Quantifying cell cycle regulation by tissue crowding.

Carles Falcó1, Daniel J Cohen2, José A Carrillo1

  • 1Mathematical Institute, University of Oxford, Oxford, United Kingdom.

Biophysical Journal
|May 8, 2024
PubMed
Summary
This summary is machine-generated.

Cells sense tissue density and adjust their division rates accordingly, impacting cell migration. This study quantifies how crowding affects cell cycle stages during tissue expansion.

More Related Videos

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

21.1K
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

19.2K

Related Experiment Videos

Last Updated: Jun 27, 2025

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

60.4K
Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

21.1K
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

19.2K

Area of Science:

  • Cell biology
  • Biophysics
  • Mathematical modeling

Background:

  • Cell proliferation and migration are crucial for development and tissue repair.
  • Mechanical forces and tissue crowding influence cell division rates.
  • The precise impact of cell cycle regulation on cell migration remains unclear.

Purpose of the Study:

  • To develop a minimal continuum model integrating cell migration and cell cycle dynamics.
  • To quantify the effects of tissue crowding on cell proliferation across different cell cycle stages.
  • To elucidate the relationship between density-dependent proliferation and cell migration patterns.

Main Methods:

  • Minimal continuum modeling of cell migration with cell cycle dynamics.
  • Bayesian inference for parameter estimation.
  • Analysis of experimental data from epithelial tissue expansion.

Main Results:

  • The model demonstrates density-dependent regulation of cell cycle progression during G1 and S/G2/M phases.
  • Quantified relationships between cell cycle stage duration and local tissue density.
  • Model predictions align with experimental observations of cell cycle regulation and migration.

Conclusions:

  • Cells dynamically adjust proliferation rates in response to local tissue density.
  • Density-sensing mechanisms provide mechanistic insights into collective cell migration.
  • The study offers a systematic framework for analyzing cell cycle data in the context of tissue dynamics.