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Updated: Jun 27, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Gold(I)-Catalyzed Regioselective Synthesis of Indenylidene Derivatives via 1,5-Acryl Migration
Galla V Karunakar1,2, Perla Bharath Kumar1,2, Pammi Venkata Rami Reddy1,2
1Fluoro Agrochemicals Department, CSIR-Indian Institute of Chemical Technology, 500007, Hyderabad, India.
Abstract:
A novel gold (I)-catalyzed synthetic strategy has been achieved for an efficient construction of indenylidene derivatives from substituted 1,6-diynes. This reaction describes the unique reactivity of gold catalysis in facilitating the intramolecular [3,3]-sigmatropic rearrangement, 5-exo dig cyclization followed by 1,5-migration of acryl group, resulting in the formation of substituted indenylidenes. Various substituted indenylidenes were successfully synthesized with up to 92 % yields. In this protocol, two new C-C bonds were sequentially formed atom economically in one pot.
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