Related Experiment Video
Updated: Jun 27, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES
Xu Wu1,2,3, Yuyang Zhang1,2,3, Hui Jiang4
1Department of Urology, First Affiliated Hospital of Anhui Medical University, Shushan District, Hefei 230022, Anhui, China.
Background:
The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has become a novel inflammation marker with a possible association with erectile dysfunction (ED); however, there are fewer studies exploring the association between MHR and ED.
Aim:
This study sought to explore the association between MHR and ED.
Methods:
This study population was drawn from participants in two 2-year cycles of the National Health and Nutrition Examination Survey (2001-2002 and 2003-2004). MHR was calculated as the ratio of monocyte count (103 cells/μL) to high-density lipoprotein cholesterol (mg/dL). The relationship between MHR and ED was explored using survey-weighted logistic regression models with MHR as a continuous variable and divided into tertiles (tertile 1 [T1]: <0.01; T2: 0.01-0.014; T3: >0.014). We also used a smooth curve fit (penalized spline method) to characterize the dose-response relationship between MHR and ED. In addition, subgroup analyses based on age, body mass index, smoking, hypertension, diabetes mellitus, and cardiovascular disease were performed to further analyze the data. Sensitivity analyses were also conducted to further assess the stability of the results.
Outcomes:
The main outcome measure was the difference in ED prevalence between MHR levels.
Results:
A total of 1361 participants were enrolled, with 513 (T1), 438 (T2), and 410 (T3) participants in the 3 MHR groups. After adjusting for all potential covariates, survey-weighted logistic regression analyses showed a significant association between MHR and ED (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.26-3.05). When MHR was used as a categorical variable, the adjusted OR for ED prevalence increased significantly with increasing MHR after adjusting for all potential covariates (T3 vs T1: OR, 2.14; 95% CI, 1.29-3.55). The dose-response curves showed that the prevalence of ED increased with increasing MHR.
Clinical Implications:
Easy to access and low cost, MHR is a convenient clinical tool that helps clinicians in the prevention and treatment of ED.
Strengths And Limitations:
The present study is the first to examine the association between MHR and ED nationally representative data. However, the study population was derived from a U.S. database, so the findings are limited to the U.S. population.
Conclusion:
Our study demonstrated that MHR levels were independently associated with ED and that ED patients had higher MHR levels, suggesting that MHR may be a valuable predictor for identifying people at higher risk for ED.
Insights
The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is linked to erectile dysfunction (ED). Higher MHR levels indicate an increased risk of ED, suggesting MHR
Area of Science:
- Cardiovascular Health
- Inflammation Markers
- Men's Health
Background:
- The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is an emerging inflammation marker.
- Limited research exists on the association between MHR and erectile dysfunction (ED).
Purpose of the Study:
- To investigate the association between MHR and ED using a nationally representative U.S. population sample.
- To determine if MHR can serve as a predictor for ED risk.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (2001-2004).
- Calculated MHR and analyzed its relationship with ED using logistic regression and dose-response curves.
- Performed subgroup and sensitivity analyses to validate findings.
Main Results:
- A significant association was found between higher MHR levels and increased ED prevalence.
- Adjusted odds ratios indicated a 2.14-fold increased risk of ED for the highest MHR tertile compared to the lowest.
- Dose-response analysis confirmed that ED prevalence rises with increasing MHR.
Conclusions:
- MHR is independently associated with ED.
- Elevated MHR levels in ED patients suggest MHR's potential as a valuable predictor for identifying individuals at higher risk of ED.
- MHR is a cost-effective clinical tool for ED prevention and treatment.
More Related Videos
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:29Cholesterol: Significance and Regulation
Considering cholesterol and...
01:20Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....