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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Jun 27, 2025

Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules

Published on: December 16, 2021

Proteomics data in vitiligo: a scoping review.

Danique Berrevoet¹, Filip Van Nieuwerburgh¹, Dieter Deforce¹

¹Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Frontiers in Immunology

|May 8, 2024

Summary

This summary is machine-generated.

Proteomics studies in vitiligo show limited overlap in identified proteins, hindering biomarker discovery. Harmonizing methods is crucial for reliable vitiligo research and identifying treatment targets.

Keywords:

biomarkers disease activity proteins proteomics vitiligo

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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

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Area of Science:

Dermatology
Biochemistry
Proteomics

Background:

Vitiligo is a condition with complex pathogenesis.
Proteomics offers potential for identifying biomarkers and treatment targets in vitiligo.

Purpose of the Study:

To conduct a scoping review of proteomics studies in vitiligo.
To assess the consistency and value of current proteomics research in vitiligo.

Main Methods:

Systematic literature search for articles using proteomics in vitiligo.
Analysis of differentially expressed proteins across identified studies.

Main Results:

Eight studies were identified, but showed very limited overlap (5.51%) in differentially expressed proteins.
Significant variability was observed in protein types, acute phase protein prevalence, and study methodologies.
More recent studies focusing on treatment response showed improved robustness.

Conclusions:

Current proteomics research in vitiligo has provided limited corroborating evidence for biomarkers.
Inconsistent methodologies and reporting hinder progress.
Harmonization of study design and proteomics methods is recommended for future research, clinical trials, and identifying reliable biomarkers or drug targets.