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Celiac disease - a pluripathological model in pediatric practice
Vasile Valeriu Lupu1, Maria Oana Sasaran2, Elena Jechel1
1Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Frontiers in Immunology
|May 8, 2024
Summary
Celiac disease (gluten enteropathy) presents with diverse symptoms beyond typical gastrointestinal issues. Recognizing atypical signs is crucial for early diagnosis and effective management, especially in children.
Area of Science:
- Gastroenterology
- Pediatrics
- Autoimmunology
Background:
- Celiac disease is a chronic autoimmune disorder affecting all age groups, with a notable prevalence in pediatrics.
- Its presentation is often chameleon-like, encompassing both classic and atypical symptoms.
- The condition significantly impacts children's growth and development.
Purpose of the Study:
- To review and highlight the atypical presentations of celiac disease.
- To guide clinicians in considering celiac disease in differential diagnoses.
- To provide updated information on celiac disease management and comorbidities.
Main Methods:
- A literature review of recent articles from international databases was conducted.
- Current theories and approaches to celiac disease and its atypical manifestations were analyzed.
Main Results:
- Atypical celiac disease presentations include constitutional, dermatological, mucosal, bone, neuropsychiatric, renal, and reproductive issues.
- Disorders of biological constants and associations with multiple autoimmune conditions are also noted.
- Early recognition of these varied symptoms is key to optimal patient outcomes.
Conclusions:
- Understanding atypical celiac disease manifestations is vital for timely diagnosis and intervention.
- Integrating knowledge of these varied presentations improves patient management and reduces disease burden.
- This review emphasizes the importance of considering celiac disease in a broad differential diagnosis.
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