Prognostic value of RNF113A shows a correlation with immune infiltrates in colorectal cancer
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View abstract on PubMed
Summary
This summary is machine-generated.RNF113A is overexpressed in colorectal cancer (CRC) and shows diagnostic and prognostic value. This gene negatively correlates with immune cell infiltration, suggesting its role as a prognostic biomarker for CRC.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- Colorectal cancer (CRC) remains a significant global health challenge.
- Identifying novel biomarkers for CRC diagnosis and prognosis is crucial.
Purpose Of The Study
- To investigate the prognostic significance of RNF113A in CRC.
- To explore the relationship between RNF113A expression and immune cell infiltration in CRC.
Main Methods
- Analysis of publicly available datasets to assess RNF113A expression and its correlation with CRC survival.
- Protein expression analysis in CRC cell lines.
- Pathway enrichment analysis.
- Correlation analysis with immune cell infiltration using TIMER and TISIDB databases.
Main Results
- RNF113A is overexpressed in CRC and demonstrates diagnostic and prognostic value (AUC=0.885).
- RNF113A expression correlates with the rRNA processing pathway.
- RNF113A expression is negatively associated with the infiltration of memory B cells, NK cells, Th2 cells, and CD8+ T cells.
Conclusions
- RNF113A serves as a potential prognostic biomarker for CRC.
- RNF113A may influence CRC progression through the rRNA processing pathway.
- RNF113A expression is linked to reduced immune cell infiltration in the tumor microenvironment.
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