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  11. Hsa_circ_0051908 Promotes Hepatocellular Carcinoma Progression By Regulating The Epithelial-mesenchymal Transition Process

Hsa_circ_0051908 Promotes Hepatocellular Carcinoma Progression by Regulating the Epithelial-Mesenchymal Transition Process

Yinbing Wu1, Huafei Tang1, Shuzhong Cui1

  • 1Department of Hepatobiliary Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.

Analytical Cellular Pathology (Amsterdam)
|May 8, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Hsa_circ_0051908 promotes hepatocellular carcinoma (HCC) progression by enhancing cell proliferation and migration. Silencing this circular RNA inhibits tumor growth and may offer a new therapeutic strategy for HCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent malignancy with complex molecular underpinnings.
  • Circular RNAs (circRNAs) are emerging as critical regulators in various cancers, including HCC.

Purpose of the Study:

  • To investigate the role and mechanism of hsa_circ_0051908 in hepatocellular carcinoma (HCC) progression.
  • To evaluate the potential of hsa_circ_0051908 as a therapeutic target for HCC.

Main Methods:

  • Quantitative real-time PCR (RT-qPCR) for expression analysis.
  • Cellular assays (CCK-8, EdU, TUNEL, flow cytometry, transwell) for proliferation, apoptosis, invasion, and migration.
  • Western blotting for molecular mechanism investigation.
  • In vivo tumor growth studies.

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Main Results:

  • Hsa_circ_0051908 expression was upregulated in HCC tissues and cell lines.
  • Knockdown of hsa_circ_0051908 suppressed HCC cell proliferation, migration, and invasion while increasing apoptosis.
  • Silencing hsa_circ_0051908 affected epithelial-mesenchymal transition (EMT) markers (vimentin, Snail, E-cadherin).
  • In vivo, hsa_circ_0051908 inhibition significantly reduced tumor growth.

Conclusions:

  • Hsa_circ_0051908 promotes HCC progression, partly via mediating EMT.
  • Hsa_circ_0051908 represents a potential therapeutic target for hepatocellular carcinoma treatment.