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Artificial amniotic fluid for nuclear magnetic resonance spectroscopy studies
Doshina Naila1,2, Siddharth Sadanand1,2,3, Dafna Sussman1,2,3,4,5
1Department of Electrical, Computer, and Biomedical Engineering Ryerson University Toronto Canada.
Analytical Science Advances
|May 8, 2024
Summary
Developing a synthetic amniotic fluid phantom using magnetic resonance spectroscopy (MRS) offers a non-invasive alternative to amniocentesis for diagnosing fetal conditions. This phantom allows for efficient testing and optimization of MRS sequences.
Area of Science:
- Biomedical Engineering
- Medical Diagnostics
- Spectroscopy
Background:
- Amniocentesis is an invasive prenatal diagnostic method with risks.
- A non-invasive alternative is needed for fetal disease diagnosis.
- Magnetic Resonance Spectroscopy (MRS) shows potential for non-invasive diagnostics.
Purpose of the Study:
- To develop a synthetic amniotic fluid (AF) phantom for MRS testing.
- To enable efficient development and optimization of MRS sequences for fetal diagnostics.
- To create a reproducible phantom for validating non-invasive diagnostic tools.
Main Methods:
- Protocol for creating a synthetic AF phantom.
- Validation of the phantom using Nuclear Magnetic Resonance (NMR).
- Comparison of phantom spectra with literature data.
Main Results:
- The synthetic AF phantom produces NMR spectra comparable to literature values.
- The phantom is suitable for testing and optimizing MRS sequences.
- Demonstrated feasibility of a synthetic phantom for MRS development.
Conclusions:
- A synthetic AF phantom can be created for MRS development.
- This phantom facilitates the creation of non-invasive fetal diagnostic tools.
- The study supports replacing invasive amniocentesis with MRS-based diagnostics.
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