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  1. Home
  3. Treatment-related Mortality Among Children With Cancer In Denmark During 2001-2021.
  1. Home
  3. Treatment-related Mortality Among Children With Cancer In Denmark During 2001-2021.

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Treatment-related mortality among children with cancer in Denmark during 2001-2021.

Marie C L Sørensen1, Mie M Andersen1, Klaus Rostgaard2

  • 1Department of Paediatric Haematology and Oncology, Department of Paediatric and Adolescence Medicine, Juliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark; Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.

Acta Oncologica (Stockholm, Sweden)
|May 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Treatment-related deaths in children with cancer remain stable despite intensified therapies. Risk factors like relapse and stem cell transplant require patient-specific approaches to prevent fatalities.

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Area of Science:

  • Pediatric Oncology
  • Cancer Treatment Complications
  • Public Health

Background:

  • Childhood cancer survival rates have improved due to intensified treatments.
  • Intensified cancer therapies can lead to fatal complications.
  • This study examines treatment-related deaths in children with cancer in Denmark from 2001-2021.

Purpose of the Study:

  • To assess temporal changes in treatment-related death incidence.
  • To identify risk factors associated with treatment-related death in pediatric cancer patients.
  • To inform strategies for reducing treatment-related mortality.

Main Methods:

  • Retrospective cohort study of 3,255 children diagnosed with cancer before age 15.
  • Cumulative incidence of treatment-related death within 5 years was estimated using Aalen-Johansen estimators.
  • Cox regression was used to identify associated risk factors.

    • Main Results:

    • 93 children (2.9% of total) died from treatment-related causes.
    • Treatment-related deaths decreased from 3.3% (2001-2010) to 2.5% (2011-2021).
    • Risk factors included female sex, young age, relapse, stem cell transplant, CNS involvement, and metastasis.

    Conclusions:

    • Treatment-related death incidence remained stable over 20 years in Denmark.
    • Clinical vigilance is crucial for preventing treatment-related deaths, especially in hematological cancers.
    • Patient-specific treatment strategies are supported by identified risk factors.