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  11. Prognostic Significance Of Excision Repair Cross-complementation Group 1 On Circulating Tumor Cells For Nasopharyngeal Carcinoma

Prognostic Significance of Excision Repair Cross-Complementation Group 1 on Circulating Tumor Cells for Nasopharyngeal Carcinoma

Ting Liu1, Yuanqing Li1, Junmei Song1

  • 1Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Cancer Control : Journal of the Moffitt Cancer Center
|May 8, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Excision Repair Cross-Complementation Group 1 (ERCC1) expression on circulating tumor cells (CTCs) and their subtypes can predict nasopharyngeal carcinoma (NPC) patient outcomes. This liquid biopsy approach offers a new prognostic marker for personalized cancer treatment.

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Cancer Biomarkers

Background:

  • Liquid biopsy, including circulating tumor cells (CTCs), shows promise for cancer management.
  • Prognostic value of CTCs in nasopharyngeal carcinoma (NPC) needs further clarification, especially regarding phenotypic characterization.
  • Excision Repair Cross-Complementation Group 1 (ERCC1) expression and CTC epithelial-mesenchymal transition (EMT) are linked to treatment efficacy.

Purpose of the Study:

  • To evaluate the prognostic significance of ERCC1 expression on CTCs in NPC patients.
  • To assess the role of ERCC1 expression on different CTC subtypes (epithelial, hybrid, mesenchymal) before treatment.
  • To determine the association between ERCC1-positive CTCs and patient survival outcomes.

Main Methods:

  • Retrospective analysis of 108 locally advanced NPC patients.
Keywords:
circulating tumor cells1epithelial-mesenchymal transition3excision repair cross-complementation group 12nasopharyngeal carcinoma4

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  • Utilized CanPatrol™ CTC testing to detect and quantify CTCs.
  • Classified CTCs into epithelial, epithelial-mesenchymal hybrid, and mesenchymal subtypes.
  • Assessed ERCC1 expression (negative vs. positive) on CTCs.

    • Main Results:

    • CTCs detected in 92.6% of patients; 74% showed ERCC1 positivity.
    • Positive ERCC1 on mesenchymal CTCs correlated with advanced N stage (P = .01).
    • ERCC1 positivity on CTCs associated with poorer overall survival (OS; P = .039) and disease-free survival (DFS; P = .035).
    • Positive ERCC1 on mesenchymal CTCs linked to worse OS (P = .012) and metastasis-free survival (MFS; P = .001).

    Conclusions:

    • ERCC1 expression on CTCs may serve as a novel prognostic marker for NPC.
    • Analysis of CTC subtypes, particularly ERCC1 expression, could aid in personalized and precise NPC treatment strategies.
    prognosis5