Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bishop & Varmus: Oncogenes.

Jayant Pai Dhungat1

  • 1Professor of Medicine (Retd), Hon. Physician, Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital; Bhatia Hospital, Mumbai, Maharashtra, India.

The Journal of the Association of Physicians of India
|May 8, 2024
PubMed
Summary

This article reviews the foundational work of Bishop and Varmus on oncogenes. It highlights their discovery of cellular genes that can cause cancer when altered.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Heparin.

The Journal of the Association of Physicians of India·2019
Same author

Female Genital Mutilation.

The Journal of the Association of Physicians of India·2019
Same author

Revisiting Medicinal Leeches.

The Journal of the Association of Physicians of India·2019
Same author

Medical Symbols: Part-2.

The Journal of the Association of Physicians of India·2018
Same author

Medical Symbols: Part-1.

The Journal of the Association of Physicians of India·2018
Same author

Nicolae Paulescu and Insulin.

The Journal of the Association of Physicians of India·2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The discovery of oncogenes revolutionized cancer research.
  • Understanding the genetic basis of cancer is crucial for developing targeted therapies.

Purpose of the Study:

  • To provide a historical overview of the discovery of oncogenes.
  • To explain the significance of the work by Bishop and Varmus in cancer genetics.

Main Methods:

  • Literature review of seminal research on oncogenes.
  • Historical analysis of key experiments and findings.

Main Results:

  • Identification of proto-oncogenes as normal cellular genes.
  • Demonstration that viral oncogenes have cellular origins.

Conclusions:

  • The work of Bishop and Varmus laid the groundwork for modern cancer genetics.
  • Oncogene research continues to be a vital area for understanding and treating cancer.

Related Experiment Videos