Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines

Area of Science:

• Electrochemistry
• Organic Synthesis
• Analytical Chemistry

Background:

• Combinatorial electrochemistry offers potential for rapid screening and synthesis.
• A novel high-throughput electrochemistry platform, Legion, provides individual control over 96 cells.
• Integrating electrochemistry with mass spectrometry is crucial for analyzing reaction products.

Purpose of the Study:

• To demonstrate the utility of the Legion platform coupled with high-throughput mass spectrometry (MS).
• To showcase the application in electrosynthetic product screening and quantitation.
• To validate the combined approach for accelerating electro-organic synthesis discovery.

Main Methods:

• Utilized the Legion high-throughput electrochemistry platform for arrayed synthesis.
• Employed nanoelectrospray ionization mass spectrometry (MS) for product analysis.
• Optimized the electrosynthesis of benzophenone azine as a model reaction.

Main Results:

• Successfully demonstrated the simultaneous control of 96 electrochemical cells using Legion.
• Achieved efficient screening and quantitation of electrosynthetic products.
• Validated the combined Legion-MS system for reaction optimization.

Conclusions:

• The integration of Legion and MS is a powerful strategy for accelerating electro-organic synthesis.
• This high-throughput approach significantly enhances reaction discovery and optimization.
• Legion's versatility is highlighted for its application in complex synthetic challenges.