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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Valence Bond Theory02:42

Valence Bond Theory

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Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
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Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

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Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

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Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

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Bimetallic Cu@Ru Core-Shell Structures with Ligand Effects for Endo-Exogenous Stimulation-Mediated Dynamic

Nannan Zheng1, Xin Hu1, Li Yan1

  • 1College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, P. R. China.

Nano Letters
|May 8, 2024
PubMed
Summary

Bimetallic copper and ruthenium nanoparticles enhance tumor treatment by generating reactive oxygen species (ROS) through combined internal and external stimuli. This novel approach effectively induces cancer cell apoptosis and ferroptosis for synergistic therapy.

Keywords:
core−shell structuredynamic oncotherapyendo−exogenous stimulationligand effects

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Synthesis of Bimetallic Pt/Sn-based Nanoparticles in Ionic Liquids
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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Oncology

Background:

  • Dynamic therapies show promise for cancer treatment by producing reactive oxygen species (ROS) in situ.
  • Tumor complexity often limits the effectiveness of single-stimulus dynamic therapies.
  • Developing multi-stimulus approaches is crucial for enhancing therapeutic efficacy.

Purpose of the Study:

  • To investigate the potential of bimetallic copper and ruthenium (Cu@Ru) core-shell nanoparticles for synergistic tumor treatment.
  • To explore the use of endo-exogenous stimulation for enhanced ROS generation.
  • To evaluate the efficacy of Cu@Ru nanoparticles in inducing tumor cell apoptosis and ferroptosis.

Main Methods:

  • Synthesis of Cu@Ru core-shell nanoparticles with regulated electronic structures.
  • Utilizing ultrasound and light stimulation to trigger ROS generation at the nanoparticle interface.
  • Assessing ROS production and its impact on tumor cells in vitro and in vivo.
  • Investigating the mechanisms of tumor cell apoptosis and ferroptosis induction.

Main Results:

  • Cu@Ru nanoparticles effectively enhanced ROS generation through combined endo-exogenous stimulation.
  • The core-shell heterojunction facilitated rapid separation of electron-hole pairs, boosting ROS production.
  • In vitro and in vivo studies confirmed Cu@Ru nanoparticles induced significant tumor cell apoptosis and ferroptosis.
  • Synergistic therapeutic effects were observed, surpassing individual stimulus-triggered therapies.

Conclusions:

  • Cu@Ru core-shell nanoparticles offer a promising platform for synergistic tumor treatment.
  • Endo-exogenous stimulation-triggered ROS generation is an effective strategy for enhancing cancer therapy.
  • This study presents a novel paradigm for advanced cancer treatment modalities.