Bimetallic Cu@Ru Core-Shell Structures with Ligand Effects for Endo-Exogenous Stimulation-Mediated Dynamic...

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Oncology

Background:

• Dynamic therapies show promise for cancer treatment by producing reactive oxygen species (ROS) in situ.
• Tumor complexity often limits the effectiveness of single-stimulus dynamic therapies.
• Developing multi-stimulus approaches is crucial for enhancing therapeutic efficacy.

Purpose of the Study:

• To investigate the potential of bimetallic copper and ruthenium (Cu@Ru) core-shell nanoparticles for synergistic tumor treatment.
• To explore the use of endo-exogenous stimulation for enhanced ROS generation.
• To evaluate the efficacy of Cu@Ru nanoparticles in inducing tumor cell apoptosis and ferroptosis.

Main Methods:

• Synthesis of Cu@Ru core-shell nanoparticles with regulated electronic structures.
• Utilizing ultrasound and light stimulation to trigger ROS generation at the nanoparticle interface.
• Assessing ROS production and its impact on tumor cells in vitro and in vivo.
• Investigating the mechanisms of tumor cell apoptosis and ferroptosis induction.

Main Results:

• Cu@Ru nanoparticles effectively enhanced ROS generation through combined endo-exogenous stimulation.
• The core-shell heterojunction facilitated rapid separation of electron-hole pairs, boosting ROS production.
• In vitro and in vivo studies confirmed Cu@Ru nanoparticles induced significant tumor cell apoptosis and ferroptosis.
• Synergistic therapeutic effects were observed, surpassing individual stimulus-triggered therapies.

Conclusions:

• Cu@Ru core-shell nanoparticles offer a promising platform for synergistic tumor treatment.
• Endo-exogenous stimulation-triggered ROS generation is an effective strategy for enhancing cancer therapy.
• This study presents a novel paradigm for advanced cancer treatment modalities.