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Bidirectional association between pneumonia and intestinal infection: an analysis of the MIMIC-IV database

Weiqian Hou1,2, Yi Zhu1, Xigui Lai3

  • 1The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.

Internal and Emergency Medicine
|May 8, 2024
PubMed

Insights

Pneumonia patients in intensive care units (ICUs) have a higher risk of intestinal infection. While not impacting mortality, concurrent intestinal infections significantly prolong ICU and hospital stays for pneumonia patients.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Gastroenterology

Background:

  • Pneumonia is a common critical illness in intensive care units (ICUs).
  • Intestinal infections are potential complications in critically ill patients.
  • The bidirectional relationship between pneumonia and intestinal infection requires further investigation.

Purpose of the Study:

  • To analyze the prevalence of intestinal infection in ICU patients with pneumonia.
  • To assess the impact of intestinal infection on the prognosis of pneumonia patients.
  • To explore the association between pneumonia and intestinal infection in the ICU setting.

Main Methods:

  • Utilized the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.
  • Employed multivariate logistic regression, propensity score matching (PSM), and inverse probability of treatment weighting (IPTW).
  • Analyzed 28-day mortality, ICU length of stay, and hospital length of stay.

Main Results:

  • Pneumonia patients exhibited a significantly increased incidence of intestinal infection (OR 1.58).
  • Intestinal infection did not significantly affect 28-day mortality in pneumonia patients (P=0.223).
  • Patients with concurrent intestinal infections had longer ICU and hospital stays (P<0.001).

Conclusions:

  • Pneumonia is associated with a higher likelihood of developing intestinal infection in ICU patients.
  • Concurrent intestinal infections prolong the length of stay for pneumonia patients in ICUs and hospitals.
  • Further research may explore targeted interventions for intestinal infections in pneumonia patients.
Keywords:
Intestinal infectionLung–gut axisMIMIC-IVPneumonia

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