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Single-Atom-Based Nanoenzyme in Tissue Repair.

Ziliang Fu^1,2, Kexin Fan^1,2, Xingjian He^1,2

¹Cardiac and Osteochondral Tissue Engineering (COTE) Group, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.

|May 8, 2024

Summary

Metal single-atom nanozymes offer a promising, efficient alternative to natural enzymes for tissue repair. Their reactive oxygen species scavenging abilities are key to promoting healing and clinical translation.

Keywords:

applications catalytic mechanism enzyme-like activity metal-based nanozymes nanozyme single-atom nanozymes tissue repair wound healing

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Area of Science:

Biomaterials Science
Nanotechnology
Enzyme Mimics

Background:

Nanozymes, inspired by Fe3O4 nanoparticles, are emerging as superior alternatives to natural enzymes.
Metal single-atom nanozymes (SAzymes) show rapid development due to cost-effectiveness, stability, and high efficiency.

Purpose of the Study:

To systematically review metal single-atom nanozymes.
To highlight their catalytic mechanisms and applications in tissue repair.
To identify challenges and propose future research directions.

Main Methods:

Literature review of metal single-atom nanozymes.
Analysis of catalytic mechanisms.
Evaluation of applications in tissue repair.

Main Results:

Single-atom nanozymes exhibit enzyme-like activity and high efficiency.
They effectively scavenge reactive oxygen species, aiding tissue repair.
Various metal-based SAzymes have demonstrated potential in regenerative medicine.

Conclusions:

Metal single-atom nanozymes are highly promising for tissue repair applications.
Further research is needed to address existing challenges for clinical translation.
SAzymes represent a significant advancement in biomaterials for regenerative medicine.