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Related Concept Videos

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Updated: Jun 26, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Interactions between platelets and the cancer immune microenvironment.

Nuerye Tuerhong1, Yang Yang1, Chenyu Wang2

  • 1Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37, GuoXue Xiang Chengdu, Sichuan, China; West China Biomedical Big Data Center, Sichuan University, No. 37, GuoXue Xiang Chengdu, Sichuan, China.

Critical Reviews in Oncology/Hematology
|May 8, 2024
PubMed
Summary

Platelets influence cancer progression and immune evasion. Understanding platelet roles in the tumor microenvironment may lead to novel cancer immunotherapies targeting platelet functions.

Keywords:
Adaptive immunityBlood plateletsImmunomodulationImmunotherapyInnate immunityNeoplasmsPlatelet inhibitionTumor escape

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Area of Science:

  • Oncology
  • Immunology
  • Hematology

Background:

  • Cancer remains a leading cause of death globally, characterized by high incidence and low cure rates.
  • Tumor development and progression are intrinsically linked to immune function.
  • Platelets, traditionally known for hemostasis, significantly impact tumor spread and progression via immune microenvironment interactions.

Purpose of the Study:

  • To provide an overview of the complex relationship between platelets and the tumor immune microenvironment.
  • To elucidate how platelets can modulate anti-tumor immunity and facilitate cancer immune escape.
  • To explore current and future therapeutic strategies targeting platelets for cancer immunotherapy.

Main Methods:

  • Literature review and synthesis of existing research on platelet-cancer interactions.
  • Analysis of the dual role of platelets in promoting or inhibiting anti-tumor immune responses.
  • Examination of platelet-targeting strategies in the context of tumor immunotherapy.

Main Results:

  • Platelets exhibit a dual role, capable of both protecting and harming the immune response against tumors.
  • Platelet interactions within the tumor microenvironment are crucial for cancer immune escape.
  • The specific impact of platelets on tumor growth and metastasis is context-dependent, varying with cancer type and treatment.

Conclusions:

  • Platelets are significant modulators of the tumor immune microenvironment and cancer progression.
  • Targeting platelets presents a promising avenue for developing novel cancer immunotherapies.
  • Further research into platelet-targeted therapies holds potential for improving cancer treatment outcomes.