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Updated: Jun 26, 2025

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
The metabolic fuel of paroxysmal nocturnal haemoglobinuria
Luca Guarnera1,2, Valeria Visconte1
1Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Abstract:
Metabolic reprogramming has been investigated in haematological malignancies. To date, a few studies have analysed the metabolic profile of paroxysmal nocturnal haemoglobinuria (PNH). The study by Chen and colleagues sheds light on the involvement of metabolic changes in the proliferation of PNH clones. Commentary on: Chen et al. The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of PNH clones through cell metabolic reprogramming. Br J Haematol 2024;204:2468-2479.
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