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Related Experiment Videos

Ceruletide intravenous dose-response study by a simplified scintigraphic technique.

G T Krishnamurthy, F E Turner, D Mangham

    AJR. American Journal of Roentgenology
    |April 1, 1985
    PubMed
    Summary

    A simplified scintigraphic technique reliably determined the intravenous dose response of ceruletide diethylamine (ceruletide). A 5 ng/kg dose yielded the most physiologic gallbladder emptying, while higher doses caused adverse reactions.

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    Area of Science:

    • Nuclear medicine
    • Gastroenterology
    • Pharmacology

    Background:

    • Ceruletide diethylamine (ceruletide) is a cholecystokinin-like agent used to assess gallbladder function.
    • Establishing a reliable intravenous dose-response for ceruletide is crucial for accurate gallbladder emptying studies.
    • Traditional methods may require multiple patient visits or complex protocols.

    Purpose of the Study:

    • To establish the intravenous dose response of ceruletide diethylamine (ceruletide) using a simplified, single-occasion scintigraphic technique.
    • To determine the optimal dose of ceruletide for achieving physiologic gallbladder emptying.
    • To assess the safety and adverse reactions associated with different intravenous doses of ceruletide.

    Main Methods:

    • A simplified scintigraphic technique was employed, administering multiple graded doses of ceruletide sequentially on a single occasion.

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  • Gallbladder volume was quantified nongeometrically using 99mTc-IDA counts.
  • Ejection fractions were calculated at intravenous doses of 1, 5, 10, and 15 ng/kg.

    • Main Results:

    • The mean ejection fractions at 1, 5, 10, and 15 ng/kg were 19.4%, 59.6%, 55.2%, and 67.8%, respectively.
    • A ceruletide dose of 5 ng/kg resulted in the most physiologic gallbladder emptying pattern.
    • Adverse reactions, including abdominal pain, nausea, hypotension, and bradycardia, occurred in 42% of doses of 10 ng/kg and higher.

    Conclusions:

    • The simplified scintigraphic technique reliably establishes the dose response of ceruletide diethylamine (ceruletide).
    • A single intravenous dose of 5 ng/kg is recommended for optimal and safe gallbladder function assessment.
    • Higher doses of ceruletide are associated with a significant incidence of adverse reactions.