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The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
Cheng An1, Zhen Li2, Yao Chen1
1Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, 230032, Anhui, China.
Cell & Bioscience
|May 9, 2024
Summary
The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway drives disease by sensing DNA. Inhibiting this innate immune pathway shows promise for treating cardiovascular diseases like heart failure.
Area of Science:
- Innate immunity
- Molecular biology
- Cardiovascular research
Background:
- The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway is a key innate immune sensor.
- Ectopic DNA, released from damaged tissues, activates cGAS-STING, triggering inflammatory responses implicated in various diseases.
- This pathway plays a significant role in the pathogenesis of cardiovascular diseases (CVDs).
Purpose of the Study:
- To identify risk factors that activate the cGAS-STING pathway.
- To elucidate the biological function of cGAS-STING in cardiovascular diseases.
- To explore the therapeutic potential of targeting the cGAS-STING pathway in CVDs.
Main Methods:
- Literature review of studies on cGAS-STING signaling.
- Analysis of research on cGAS-STING's role in cardiovascular pathologies.
- Evaluation of evidence for therapeutic interventions targeting cGAS-STING.
Main Results:
- The cGAS-STING pathway is implicated in myocardial infarction, heart failure, atherosclerosis, and aortic dissection/aneurysm.
- Inhibition of cGAS-STING can reduce myocardial hypertrophy and inflammatory cell infiltration.
- Understanding activation triggers is crucial for risk mitigation.
Conclusions:
- The cGAS-STING pathway is a critical regulator in cardiovascular disease development.
- Targeting cGAS-STING presents a promising therapeutic strategy for cardiovascular conditions.
- Further research is needed to fully harness cGAS-STING as a therapeutic target.
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