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Updated: Jun 26, 2025

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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2',4'-LNA-Functionalized 5'-S-Phosphorothioester CDNs as STING Agonists.

Simpa K Yeboah1,2, Abdulai Zigli1,2, Herman O Sintim1,2,3

  • 1Department of Chemistry, 560 Oval Drive, West Lafayette, Indiana, 47907-2084.

Chembiochem : a European Journal of Chemical Biology
|May 9, 2024
PubMed
Summary

New locked nucleic acid-functionalized cyclic dinucleotides (LNA endo-S-CDNs) show potential as immunotherapeutics. These compounds activate the cGAS-STING pathway and exhibit enhanced chemical and enzymatic stability for cancer vaccines.

Keywords:
5’-S-phosphorothioesterCyclic DinucleotidePDESTING AgonistcGAMPhydrolytically stablephosphorothioate

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