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Spesolimab: Is it a new treatment target in palmoplantar pustulosis?

Hanjing Huang1,2, Yuru Zhang1,2, Yuanhao Wu1,2

  • 1Department of Rheumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

International Journal of Rheumatic Diseases
|May 9, 2024
PubMed
Abstract

No abstract available in PubMed .

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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