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Prevalence of beta-lactamase-producing bacteria in chronic suppurative otitis media

I Brook

    American Journal of Diseases of Children (1960)
    |March 1, 1985
    PubMed

    Insights

    Beta-lactamase-producing bacteria, including Bacteroides and Pseudomonas, were frequently found in children with chronic suppurative otitis media. These resistant organisms may explain why penicillin therapy sometimes fails in treating this common ear infection.

    Area of Science:

    • Microbiology
    • Pediatric Otolaryngology
    • Infectious Diseases

    Background:

    • Chronic suppurative otitis media (CSOM) is a persistent middle ear infection.
    • Identifying causative pathogens and their resistance patterns is crucial for effective treatment.
    • Penicillin therapy failure is a concern in managing CSOM.

    Purpose of the Study:

    • To investigate the aerobic and anaerobic bacterial isolates in pediatric CSOM.
    • To determine the prevalence of beta-lactamase-producing organisms in CSOM exudates.
    • To assess the potential role of these resistant bacteria in treatment failure.

    Main Methods:

    • Exudate aspiration via open perforation in 48 children with CSOM.
    • Isolation and identification of aerobic and anaerobic bacteria.
    • Detection of beta-lactamase production in recovered isolates.
    • Correlation of bacterial findings with recent penicillin treatment history.

    Main Results:

    • A high prevalence of both aerobic and anaerobic bacteria was observed in CSOM.
    • Common isolates included Bacteroides melaninogenicus group, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus.
    • Beta-lactamase-producing organisms were found in 69% of patients, with significant numbers isolated from those recently treated with penicillin.
    • Specific beta-lactamase producers like S aureus, Bacteroides fragilis group, and P aeruginosa were noted.

    Conclusions:

    • Bacterial resistance, particularly beta-lactamase production, is common in pediatric CSOM.
    • The presence of these resistant organisms is strongly associated with recent penicillin treatment.
    • Beta-lactamase-producing bacteria likely contribute to the failure of penicillin therapy in CSOM.

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