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Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia
Jeewon Suh1,2,3, Young Ho Park1,2, Hang-Rai Kim4
1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
Dementia and Neurocognitive Disorders
|May 9, 2024
Summary
Transient global amnesia (TGA) patients may have pre-existing brain abnormalities. Brain MRI volumetric analysis revealed reduced volume in the bilateral ventral anterior cingulate cortices of TGA patients.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Transient global amnesia (TGA) is a neurological condition characterized by sudden, temporary memory loss.
- The underlying causes and potential pre-existing brain abnormalities in TGA patients remain incompletely understood.
Purpose of the Study:
- To investigate pre-existing structural brain abnormalities in patients with acute transient global amnesia (TGA).
- To utilize volumetric analysis of brain magnetic resonance imaging (MRI) to identify structural differences between TGA patients and healthy controls.
Main Methods:
- Brain MRI data from 87 TGA patients and 20 age- and sex-matched controls were analyzed.
- MRI scans were acquired within 72 hours of TGA symptom onset to assess for pre-existing changes.
- Voxel-based morphometry and statistical parametric mapping were employed to compare brain structures.
Main Results:
- Significant reductions in brain volume were observed in the bilateral ventral anterior cingulate cortices of TGA patients compared to controls.
- These volumetric differences were statistically significant after correction (p<0.05).
Conclusions:
- The findings suggest that TGA patients may possess pre-existing structural alterations in the bilateral ventral anterior cingulate cortices.
- These structural changes might predispose individuals to TGA episodes.
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