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  11. Association Between Oxidative Balance Score And Sarcopenia In Us Adults: Nhanes 2011-2018

Association between oxidative balance score and sarcopenia in US adults: NHANES 2011-2018

Weihang Xu1,2, Dongmei Mu1,2, Yuehui Wang3

  • 1Division of Clinical Research, The First Hospital of Jilin University, Changchun, China.

Frontiers in Nutrition
|May 9, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

The Oxidative Balance Score (OBS) is linked to lower sarcopenia prevalence in American adults. Higher OBS may protect against muscle loss, particularly in older, educated individuals and those with chronic diseases.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Public Health

Background:

  • Sarcopenia, defined by reduced muscle mass, strength, and function, is associated with inflammation and oxidative stress.
  • The relationship between sarcopenia and the Oxidative Balance Score (OBS) is not well-established.
  • Limited research exists on factors influencing sarcopenia, highlighting a gap in understanding its complex etiology.

Purpose of the Study:

  • To investigate the association between the Oxidative Balance Score (OBS) and sarcopenia prevalence in a representative US adult population.
  • To explore how dietary and lifestyle factors contributing to OBS may influence skeletal muscle health.
  • To identify demographic and clinical subgroups where this association is more pronounced.

Main Methods:

  • Utilized data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES).
Keywords:
NHANESoxidative balance scoreoxidative stresssarcopenia

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  • Calculated OBS using 16 dietary and 4 lifestyle factors; sarcopenia was defined by appendicular skeletal muscle mass (ASM) adjusted for body mass index (BMI).
  • Employed weighted logistic regression, sensitivity analysis, subgroup analysis, and interaction tests to assess the association.

    • Main Results:

    • A significant negative association was found between OBS and sarcopenia (OR=0.942, p<0.001) in 6,677 adults aged 20-59.
    • Stronger associations were observed between diseases and both dietary and lifestyle components of OBS.
    • The negative association between OBS and sarcopenia was more pronounced in older, more educated individuals, and those with comorbidities like hypertension, diabetes, cancer, and arthritis.

    Conclusions:

    • This study demonstrates a significant association between a higher Oxidative Balance Score (OBS) and a lower prevalence of sarcopenia among American adults.
    • The findings suggest that optimizing dietary and lifestyle factors to improve OBS may be a potential strategy for mitigating sarcopenia.
    • Further research is warranted to elucidate the mechanisms underlying this relationship and its clinical implications for muscle health across the lifespan.
    skeletal muscle