The Role of Continuous Positive Airway Pressure (CPAP) Therapy in Obstructive Sleep Apnea With Metabolic Syndrome:...

Area of Science:

• Cardiology
• Endocrinology
• Sleep Medicine

Background:

• Obstructive sleep apnea (OSA) is linked to metabolic syndrome, increasing cardiovascular mortality risk.
• Metabolic syndrome comprises hypertension, insulin resistance, and dyslipidemia.
• OSA's impact on metabolic syndrome requires further investigation.

Purpose of the Study:

• To evaluate the effect of continuous positive airway pressure (CPAP) on metabolic syndrome components in OSA patients.
• To determine if CPAP therapy can reverse metabolic syndrome.

Main Methods:

• Prospective pre-post study at a tertiary care center.
• Included patients with moderate to severe OSA, aged over 18, naive to CPAP.
• Assessed metabolic syndrome components before and after 3 months of CPAP therapy.

Main Results:

• 79 patients completed the study; 60.8% were male, 68.4% had hypertension.
• CPAP therapy significantly improved glycated hemoglobin (HbA1c), tetraiodothyronine (T4), high-density lipoprotein (HDL), and oxygen desaturation.
• Blood pressure, fasting/post-meal blood sugar, and triglyceride levels showed significant reductions.

Conclusions:

• CPAP therapy demonstrates significant improvements in metabolic syndrome markers.
• 17.72% of patients no longer met metabolic syndrome criteria post-CPAP.
• Age and sex influenced the response to CPAP therapy regarding specific metabolic parameters.