The Oncogenic Potential of Human Papillomavirus in Relation to Multiple Types of Cancer in Saudi Arabia: A Systematic Review
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View abstract on PubMed
Summary
This summary is machine-generated.Human papillomavirus (HPV) is linked to cervical cancer in Saudi Arabia. Evidence also suggests HPV
Area Of Science
- Oncology
- Virology
- Epidemiology
Background
- Human papillomavirus (HPV) is a known oncogenic virus.
- The association between HPV and various cancers is well-established globally.
- Limited data exists on HPV's role in cancers within the Kingdom of Saudi Arabia (KSA).
Purpose Of The Study
- To systematically review and assess the evidence linking HPV to cervical, colon, ovarian, and head and neck cancers in KSA.
- To identify the prevalent HPV types in the region.
- To evaluate the strength of association between HPV and these specific cancers.
Main Methods
- A systematic literature search was conducted following PRISMA guidelines.
- Databases searched included Web of Science, Embase, PubMed, and Cochrane Library up to May 2023.
- Study selection, data extraction, and quality assessment were performed on relevant literature.
Main Results
- High-risk HPV types, particularly HPV-16 and HPV-18, are the most prevalent in KSA.
- A significant association was found between HPV infection and cervical cancer cases in the region.
- Evidence suggests a plausible role of HPV in colonic polyps and colorectal cancer.
- Genotyping and integration analyses indicate a probable link between HPV and ovarian cancer.
- A notably reduced prevalence of HPV-related head and neck squamous cell carcinoma was observed in KSA.
Conclusions
- HPV is strongly associated with cervical cancer in KSA.
- Plausible correlations exist between HPV and squamous cell carcinomas of the colon and ovaries.
- The prevalence of HPV-related head and neck cancers is low in KSA.
- Further research is crucial to fully elucidate HPV's role in these malignancies.
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