Related Experiment Video
Updated: Jun 26, 2025

06:36
Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
7.0K
Diffuse type gastric adenocarcinoma with atypical presentation: A case report
Gidion Edwin1,2, Yohana Mbishi1,2, Francis Zerd3
1Department of Internal Medicine Benjamin Mkapa Hospital Dodoma Tanzania.
Clinical Case Reports
|May 9, 2024
Summary
Gastric adenocarcinoma, a rare malignancy, can present atypically, challenging diagnosis. Vigilance for unusual symptoms is crucial, especially in younger individuals or resource-limited settings.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gastric adenocarcinoma is a prevalent malignancy typically affecting older adults and presenting with abdominal symptoms.
- Atypical presentations, such as back pain and respiratory distress, pose diagnostic challenges, particularly in younger patients.
Observation:
- A case report details a late-30s male initially presenting with back pain, shortness of breath, and constitutional symptoms, leading to a presumptive tuberculosis diagnosis and treatment.
- The patient later developed abdominal pain and intractable vomiting, prompting further investigation.
Findings:
- Oesophagoduodenoscopy (OGD), histology, and immunohistochemistry confirmed diffuse type gastric adenocarcinoma.
- The patient succumbed to complications of advanced disease.
Implications:
- This case underscores the importance of considering gastric adenocarcinoma in diverse clinical scenarios, even with atypical symptoms or in younger patients.
- Prompt OGD and potential genetic testing are vital for timely diagnosis and effective management of gastric adenocarcinoma.
- Heightened clinical suspicion is necessary, especially in regions with endemic infectious diseases, to avoid diagnostic delays.
More Related Videos
Related Concept Videos
Gastritis-I: Introduction and Types
376
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
376
Barrett Esophagus-I: Introduction
86
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
86
Gastritis III: Clinical Manifestations and Management
228
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
228
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
113
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
113
Gastritis-II: Pathophysiology
320
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
320

