Matthew-Wood Syndrome in Monochorionic, Diamnionic Twins

Area of Science:

• Medical Genetics
• Developmental Biology
• Pediatric Medicine

Background:

• Matthew-Wood syndrome is a rare genetic disorder.
• It is characterized by diaphragmatic defects, pulmonary hypoplasia, microphthalmia/anophthalmia, and cardiac defects.
• Most cases are lethal, with few infants surviving past a few years.

Purpose of the Study:

• To review and discuss Matthew-Wood syndrome.
• To present a unique case of the syndrome in monochorionic, diamnionic twin females.
• To add to the limited understanding of this rare condition.

Main Methods:

• Literature review of Matthew-Wood syndrome.
• Case report of monochorionic, diamnionic twin females with the syndrome.
• Discussion of clinical presentation and implications.

Main Results:

• The syndrome presented in monochorionic, diamnionic twin females.
• This is the first reported case of Matthew-Wood syndrome in twins.
• The review consolidates existing knowledge and presents a novel case.

Conclusions:

• Matthew-Wood syndrome can occur in twins, a previously unreported occurrence.
• This case provides valuable insights into the variability and presentation of the syndrome.
• Further research is needed to understand the genetic and developmental factors in twin presentations.