Reference Standards for C-Peptide in Korean Population: A Korean Endocrine Hormone Reference Standard Data Center...

Area of Science:

• Endocrinology
• Clinical Chemistry
• Reference Standards

Background:

• The Korean Endocrine Hormone Reference Standard Data Center (KEHRS DC) has developed reference standards (RSs) for endocrine hormones since 2020.
• This research marks the first establishment of RSs for serum C-peptide in a healthy Korean population.

Purpose of the Study:

• To establish reference standards for serum C-peptide levels in healthy Korean adults.
• To provide a reliable baseline for clinical and research applications involving C-peptide measurements.

Main Methods:

• Recruited healthy Korean adults between May 2021 and September 2023.
• Collected serum samples, with participants choosing between fasting glucose or oral glucose tolerance tests (OGTT).
• Excluded participants with hyperglycemia (glucose ≥100 mg/dL) or high HbA1c (≥5.70%) from C-peptide analysis.

Main Results:

• Analyzed data from 1,050 participants after exclusions.
• Determined mean ± 2 standard deviations and expanded uncertainties for fasting, 30-minute, and 120-minute OGTT C-peptide levels.
• Observed correlations between serum C-peptide levels and obesity, glucose, and HbA1c.

Conclusions:

• The established reference standards for serum C-peptide are valuable for clinical practice and related scientific fields.
• These RSs contribute to accurate endocrine hormone assessment in the Korean population.