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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Choroid plexus imaging in multiple sclerosis management - a systematic review.

Justyna Wołos1, Olga Grodzka2,3, Jan Kochanowski1

  • 1Department of Neurology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

Neurologia I Neurochirurgia Polska
|May 9, 2024
PubMed
Summary

Enlarged choroid plexus (CP) in multiple sclerosis (MS) patients may serve as an early diagnostic indicator. CP imaging shows potential as a valuable tool for managing MS, a CNS disease affecting over 2 million people.

Keywords:
choroid plexusmagnetic resonance imagingmultiple sclerosisneuroinflammationplica choroidea

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Area of Science:

  • Neurology
  • Immunology
  • Radiology

Background:

  • Multiple sclerosis (MS) is a debilitating central nervous system (CNS) disease characterized by inflammation, demyelination, and neurodegeneration, impacting over 2 million individuals globally.
  • The choroid plexus (CP), primarily known for cerebrospinal fluid production, also plays a role in immune cell trafficking, which is heightened in neuroinflammatory conditions like MS.
  • Given MS's autoimmune nature, the CP's involvement in its pathogenesis, potentially indicated by altered imaging characteristics, warrants investigation.

Approach:

  • A systematic literature review was conducted following PRISMA 2020 guidelines.
  • PubMed and Embase databases were searched for relevant studies.
  • Sixteen studies were included after a thorough analysis.

Key Points:

  • Choroid plexus (CP) volume was significantly increased in multiple sclerosis (MS) patients compared to healthy controls.
  • CP enlargement may precede a definitive MS diagnosis.
  • Correlations between CP volume and brain atrophy or disease severity were reported in some studies.

Conclusions:

  • Choroid plexus imaging presents a promising avenue for novel diagnostic and management strategies in multiple sclerosis.
  • Further research into CP imaging could enhance early detection and monitoring of MS progression.