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Related Experiment Videos

Decrease in reactivity of basophils by immunotherapy with housedust extract.

I Kimura, Y Tanizaki, Y Goda

    Clinical Allergy
    |January 1, 1985
    PubMed
    Summary
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    Immunotherapy for housedust-sensitive asthma significantly reduces basophil reactivity to housedust extract and anti-immunoglobulin E (IgE). This suggests immunotherapy alters basophil surface receptors, improving asthma control.

    Area of Science:

    • Immunology
    • Allergy and Clinical Immunology
    • Cellular Biology

    Background:

    • Bronchial asthma is a chronic inflammatory airway disease.
    • Housedust mite allergy is a common trigger for asthma.
    • Immunotherapy aims to desensitize patients to specific allergens.

    Purpose of the Study:

    • To investigate the effects of immunotherapy on basophil reactivity in housedust-sensitive asthma patients.
    • To assess changes in basophil response to housedust extract and anti-IgE during immunotherapy.
    • To correlate these changes with specific IgE antibody levels.

    Main Methods:

    • Thirteen patients with bronchial asthma sensitive to housedust underwent immunotherapy.
    • Basophil reactivity was assessed morphologically and via histamine release.

    Related Experiment Videos

  • Reactivity was measured against housedust extract and anti-IgE at baseline and during therapy (6, 12, 18 months).
  • Specific IgE antibody levels to housedust were also measured.

    • Main Results:

    • A significant decrease in basophil reactivity to housedust extract was observed at 6, 12, and 18 months of immunotherapy.
    • Histamine release from basophils also decreased significantly.
    • Basophil reactivity to anti-IgE decreased significantly at 18 months.
    • Specific IgE antibody levels to housedust were reduced at 12 and 18 months.

    Conclusions:

    • Immunotherapy induces changes in basophil surface characteristics, leading to decreased cellular reactivity.
    • Reduced basophil reactivity to anti-IgE may be linked to a decrease in IgE receptors.
    • These findings suggest immunotherapy modulates basophil function in housedust-sensitive asthma.