Associations and Mediating Pathways Between Childhood Adversity and Risk of Dementia: A Cohort Study in the UK Biobank
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View abstract on PubMed
Summary
This summary is machine-generated.Childhood adversity (CA) significantly increases dementia risk. Depression, smoking, low grip strength, and certain biomarkers mediate this association, highlighting targets for dementia prevention.
Area Of Science
- Neuroscience
- Public Health
- Gerontology
Background
- Childhood adversity (CA) is linked to adverse outcomes, but its association with dementia requires further investigation.
- Previous research on CA and dementia has yielded inconsistent findings.
- Understanding the pathways linking CA to dementia is crucial for prevention strategies.
Purpose Of The Study
- To investigate the longitudinal association between childhood adversity (CA) and the risk of developing all-cause dementia.
- To quantify the extent to which potential mediators, including lifestyle, psychological, and biological factors, contribute to this association.
Main Methods
- Utilized UK Biobank data from 150,152 nondemented individuals.
- Assessed CA retrospectively via an online questionnaire; dementia incidence was determined through ICD-10 codes.
- Employed Cox proportional hazard models and mediation analyses to examine associations and mediating pathways.
Main Results
- Individuals with any CA had a 30.0% higher risk of dementia (HR=1.300).
- Each additional CA exposure correlated with a 15.5% increased dementia risk.
- Depression, smoking, low grip strength, and specific biomarkers (inflammation, erythrocyte, liver, kidney function) partially mediated the CA-dementia link.
Conclusions
- Childhood adversity (CA) is a significant risk factor for dementia.
- Depression, smoking, low grip strength, and certain biomarkers are identified as key mediators.
- Interventions targeting these modifiable mediators are essential for dementia prevention.
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