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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 26, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Mouse Models for Head and Neck Squamous Cell Carcinoma.

J Zhou¹, C Liu¹, P Amornphimoltham²

¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang, China.

Journal of Dental Research

|May 9, 2024

Summary

Choosing the right head and neck squamous cell carcinoma (HNSCC) mouse model is crucial for research. This review details chemical-induced, genetically engineered, and transplanted models, highlighting their pros and cons for HNSCC studies.

Keywords:

cancer biology carcinogens gene editing immunotherapy modeling transplantation

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Published on: January 5, 2017

Area of Science:

Oncology
Translational Research
Animal Models

Background:

Head and neck squamous cell carcinoma (HNSCC) prognosis remains poor, with limited understanding of its pathogenesis.
There is a critical need for effective animal models that accurately mimic the HNSCC microenvironment for preclinical research.

Purpose of the Study:

To provide a comprehensive overview of available HNSCC mouse models.
To analyze the characteristics, establishment methods, and applications of different HNSCC models.
To guide researchers in selecting appropriate models for their specific research needs.

Main Methods:

Review of existing literature on HNSCC mouse models.
Categorization of models into chemical-induced, genetically engineered mouse models (GEMMs), and transplanted models.
Analysis of the advantages and limitations of each model type.

Main Results:

Chemical-induced models resemble human carcinogenesis but are time-consuming and unpredictable.
GEMMs recapitulate tumor microenvironments and immune interactions but often have low tumor incidence.
Transplanted models (xenografts and syngeneic) offer consistency and efficiency, with syngeneic models being valuable for immune system studies.

Conclusions:

Each HNSCC mouse model presents unique strengths and weaknesses.
The choice of model depends on the specific research question, from studying initiation to immune interactions.
Selecting the optimal model is essential for advancing HNSCC research and improving patient outcomes.