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A morphologic study of lymphadenosis benigna cutis.
Dermatologica
|January 1, 1985
Summary
Lymphadenosis benigna cutis involves skin infiltrates with B and T cell areas. These areas mirror the microarchitecture and morphology of normal lymphatic tissue, indicating a structured immune response.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Lymphocyte Biology
Background:
- Lymphadenosis benigna cutis (LBC) is a benign skin condition.
- Understanding the cellular composition of LBC infiltrates is crucial for diagnosis.
Purpose of the Study:
- To analyze the morphological and immunological characteristics of skin biopsies from LBC.
- To compare the cellular architecture of LBC infiltrates with normal lymphatic tissue.
Main Methods:
- Morphological and immunological analysis of skin biopsies.
- Use of monoclonal and polyclonal antibodies on cryostat and paraffin sections.
- Immunophenotyping of lymphocyte populations (T cells, B cells) and other cellular components.
Main Results:
- Follicular structures in LBC contain germinal centers with cell types identical to normal lymphatic tissue (centrocytes, centroblasts, plasma cells, dendritic reticulum cells, T lymphocytes).
- The dermal infiltrate outside germinal centers consists of small T lymphocytes (OKT-3+) with an OKT-4+ to OKT-8+ ratio of 2:1.
- Indeterminate and interdigitating reticulum cells (OKT-6+) were identified within T lymphocyte-rich areas.
Conclusions:
- The dermal infiltrate in lymphadenosis benigna cutis is organized into B and T cell areas.
- These B and T cell areas exhibit the same microarchitecture and morphology as observed in normal lymphatic tissue.
- This suggests a structured immune response within the skin lesions of LBC.