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Updated: Jun 26, 2025
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Epoxy resin bioactive dental implant capped with hydroxyapatite and curcumin nanoparticles: a novel approach
1Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Dental College and Hospitals, Saveetha University, Chennai, 600 077, Tamilnadu, India. senthilbiop@gmail.com.
Objective:
In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs).
Materials And Methods:
The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility study. The scanning electron microscopy (SEM) morphology of the BDI was observed HA mineralized crystal layer after being immersed in the stimulated body fluids (SBF) solution.
Results:
The mechanical properties of the BDI exhibited tensile strength (250.61 ± 0.43 MPa), elongation at break (215.66 ± 0.87%), flexural modulus (03.90 ± 0.12 GPa), water absorption (05.68 ± 0.15%), and water desorption (06.42 ± 0.14%). The antimicrobial activity of BDI was observed in excellent zone of inhibition against the gram-negative (15.33 ± 0.04%) and gram- positive (15.98 ± 0.07%) bacteria. The biocompatibility study of BDI on osteoblasts cell line (MG-63) was analyzed using MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results were observed 85% viable cells present in the BDI compared to the control (only ER) samples.
Conclusions:
Based on the research outcome, the BDI could be used for biomaterials application, particularly tooth dental implantation.
