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Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation.

Qonita Kurnia Anjani1,2, Natalia Moreno-Castellanos3, Masoud Adhami1

  • 1School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7BL, UK.

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Summary

This study developed novel quercetin-loaded microarray patches (MAPs) to improve wound healing. These Soluplus®-enhanced MAPs effectively deliver quercetin, showing anti-inflammatory properties and biocompatibility.

Keywords:
Cell proliferationDissolving microarray patchesInflammation activityQuercetin

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Area of Science:

  • Pharmacology and Drug Delivery
  • Biomaterials Science
  • Dermatology and Wound Healing

Background:

  • Quercetin demonstrates potential for wound healing by reducing fibrosis and scar formation.
  • Poor quercetin solubility limits bioavailability, requiring high doses for therapeutic effect.
  • Novel drug delivery systems are needed to enhance quercetin's wound healing efficacy.

Purpose of the Study:

  • To develop and characterize quercetin-loaded microarray patches (MAPs) for improved wound healing.
  • To evaluate the solubility enhancement and drug loading capacity of MAPs using Soluplus®.
  • To assess the in vitro skin delivery, anti-inflammatory properties, and biocompatibility of the developed MAPs.

Main Methods:

  • Fabrication of quercetin-loaded MAPs utilizing solubility enhancement strategies, including Soluplus®.
  • Assessment of MAP mechanical properties and insertion depth into excised porcine skin.
  • In vitro skin permeation studies using full-thickness neonatal porcine skin over 24 hours.
  • Evaluation of anti-inflammatory activity and cytotoxicity assays with human keratinocyte cells.

Main Results:

  • MAPs exhibited favorable mechanical strength and skin insertion depth (650 μm).
  • Soluplus®-enhanced formulations achieved high drug loading (2.5 mg/patch) and rapid dissolution (<1 hour).
  • MAPs demonstrated over 80% quercetin delivery efficiency across skin layers within 24 hours, with significant anti-inflammatory effects and good cell biocompatibility.

Conclusions:

  • Quercetin-loaded MAPs, particularly those enhanced with Soluplus®, offer a promising strategy for wound healing.
  • This novel delivery system overcomes quercetin's solubility limitations, enhancing bioavailability and therapeutic potential.
  • The developed MAPs show potential for wound healing and anti-inflammatory applications with improved safety and efficacy.